Time to positivity in differential diagnosis of intracranial infection caused by coagulase-negative Staphylococcus
10.3760/cma.j.issn.1674-2397.2016.06.008
- VernacularTitle:阳性报警时间对成人凝固酶阴性葡萄球菌颅内感染鉴别诊断研究
- Author:
Minhui DAI
;
Pinghua PAN
;
Qian LI
;
Zhi MAO
;
Shuai LIU
;
Haitao LI
- Keywords:
Cerebrospinal fluid;
Coagulase;
Staphylococcus;
Time to positivity;
Intracranial infection
- From:Chinese Journal of Clinical Infectious Diseases
2016;9(6):518-521
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the application of time to positivity (TTP)in differential diagnosis of intracranial infection caused by coagulase-negative Staphylococcus (CNS).Methods One hundred and twenty-four adult patients with positive CNS isolated from cerebrospinal fluid (CSF)including 70 cases with intracranial infection and 54 cases of CSF contamination,who were admitted in Xiangya Hospital of Central South University during January to December 201 5,were retrospectively analyzed.The difference of TTP between two groups was compared,receiver operating characteristic (ROC)curve was analyzed and the area under the ROC curve (AUC)was calculated.The application of TTP in differential diagnosis of CNS infection was evaluated.SPSS 1 8.0 software was used to analyze the data.Results TTP in intracranial infection group was shorter than that in CSF contamination group [(23.5 ±7.5 )h vs. (37.6 ±1 0.5)h,t =-8.71 7,P =0.000].The AUC of TTP was 0.854.Taking the cut-off value of 27.94 h,the sensitivity,specificity,positive and negative predictive values in differentiation of two groups were 72.7%,91 .4%,90.0% and 72.2%,respectively.There were statistically differences in TTP of Staphylococcus epidermidis,Staphylococcus haemolyticus and Staphylococcus capitis between two groups (Z =-4.496,-2.322 and -2.399,respectively,P <0.05 or <0.01 ).Conclusion TTP can be used to discriminate early intracranial infection and CSF contamination caused by CNS,and also can identify intracranial infection caused by different categories of CNS.
