The relationship between the apolipoprotein M-sphingosine-1-phosphate axis and atherosclerosis
10.3760/cma.j.issn.1009-9158.2016.12.026
- VernacularTitle:载脂蛋白M－1－磷酸鞘氨醇轴与动脉粥样硬化
- Author:
Li TAN
;
Min HU
- Keywords:
Atherosclerosis;
Apolipoproteins;
Lipocalins;
Lysophospholipids;
Sphingosine
- From:
Chinese Journal of Laboratory Medicine
2016;39(12):983-987
- CountryChina
- Language:Chinese
-
Abstract:
Apolipoprotein M-sphingosine-1-phosphate axis ( apoM-S1P axis ) signaling pathway consists of apolipoproteinM (apoM), sphingosine-1-phosphate (S1P) and sphingosine-1-phosphate receptor (S1PR).Plasma apoM belongs to lipocalinsuperfamily members , and is mainly associated to high density lipoprotein( HDL), whereas HDL-cholesterol correlates inversely with cardiovascular risk .The ability of apoM to bind S1P is due to a lipophilic binding pocket within the lipocalin structure of the apoM molecule . S1P, a bioactive mediator of phospholipid metabolism , predominantly abound in HDL among all lipoproteins.S1P can not only be used as intracellular second messengers , but also as intercellular signal molecules, activating of G protein-coupled receptors (S1PR) to mediate various physiological functions.It′s clear that apoM protects human beings from atherosclerosis .Furthermore, recent studies showed that S1P has a significant impact on atherosclerosis , and ApoM-S1P axis may play a important role in the pathogenesis or progression of atherosclerosis .
