Prognostic significance of cytosolic phospholipase A2 expression in patients with colorectal cancer.
10.4174/jkss.2011.80.6.397
- Author:
Young Sun YOO
1
;
Sung Chul LIM
;
Kyung Jong KIM
Author Information
1. Department of Surgery, Chosun University College of Medicine, Gwangju, Korea. kjkim@chosun.ac.kr
- Publication Type:Original Article
- Keywords:
Cytosolic phospholipase A2;
Prognosis;
Colorectal cancer
- MeSH:
Calcium Hydroxide;
Colorectal Neoplasms;
Cyclooxygenase 2;
Cytosol;
Disease-Free Survival;
Humans;
Immunohistochemistry;
Kaplan-Meier Estimate;
Phospholipases;
Phospholipases A2;
Prognosis;
Recurrence;
Vascular Endothelial Growth Factor A;
Zinc Oxide
- From:Journal of the Korean Surgical Society
2011;80(6):397-403
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: Cyclooxygenase-2 is believed to be an important enzyme in the pathogenesis of colorectal cancer (CRC). Cytosolic phospholipase A2 (cPLA2), also, have been suggested to be related to the carcinogenesis of CRC. The aim of this study was to investigate cPLA2 expression and its relationship with prognostic significance in CRC. METHODS: Eighty-eight patients with colorectal cancer who underwent curative surgery were enrolled in this study. cPLA2 was examined in 88 primary CRCs by immunohistochemistry and we compared their expression with clinicopathologic findings, recurrence and survival in patients with CRC. RESULTS: The expression of cPLA2 was positive in 54.5% (48/88). The expression of cPLA2 was not correlated with clinicopathologic parameters. However, cPLA2 expression was significantly related with vascular endothelial growth factor expression. Kaplan-Meier analysis didn't show any clinical significance in disease-free survival and overall survival according to cPLA2 expression. CONCLUSION: These results suggest that cPLA2 expression was not associated with the prognosis of CRC. However, further large-scale studies are needed to clarify the prognostic effect of cPLA2 in CRC.
