Bone marrow mesenchymal stem cell transplantation alleviates myocardial injury due to systolic hypertension
10.3969/j.issn.2095-4344.2016.50.010
- VernacularTitle:骨髓间质干细胞减轻收缩期高血压的心肌损伤
- Author:
Yong WANG
;
Yaguang ZHANG
- From:
Chinese Journal of Tissue Engineering Research
2016;20(50):7518-7523
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:Mesenchymal stem cel s can be used to treat a variety of injuries, but little is known about their effect on systolic hypertension. OBJECTIVE:To study the therapeutic effect of bone marrow mesenchymal stem cel s on systolic hypertension rats. METHODS:Twenty-four rats were randomized equal y into control, model and cel transplantation groups. A rat model of systolic hypertension was made by injection of vitamin K and warfarin sodium in the model and cel transplantation groups. Rats in the cel transplantation group were given injection of bone marrow mesenchymal stem cel s into the left ventricle, while those in the other two groups given normal saline. RESULTS AND CONCLUSION:Compared with the model group, bone marrow mesenchymal stem cel s could reduce left ventricular mass index, increase cardiac tissue type I col agen volume fraction, col agen volume fraction and perivascular col agen volume fraction, but the ratio of end-diastolic volume/body weight did not change significantly. These findings indicate that bone marrow mesenchymal stem cel transplantation can reduce myocardial hypertrophy and cardiac fibrosis in systolic hypertension rats.
