Research advances on the apolipoptrotein A-I mimetic peptides
10.3969/j.issn.1005-1678.2016.12.005
- VernacularTitle:载脂蛋白A-I模拟肽的研究进展
- Author:
Xiang LIU
;
Zhijun OU
;
Yan LI
;
Jingsong OU
- Keywords:
apolipoptroteinA-I;
cardiovascular disease;
inflammation;
metabolic syndrome
- From:
Chinese Journal of Biochemical Pharmaceutics
2016;36(12):20-24
- CountryChina
- Language:Chinese
-
Abstract:
High density lipoprotein cholesterol ( HDL-C) has received extensive attention because of its cardiovascular protective effects.Recent studies showed that HDL could promote reverse cholesterol transport ( RCT ) , be anti-inflammatory and antioxidant, and induce angiogenesis. Apolipoptrotein A-I (apoA-I), the most abundant protein of HDL, plays a pivotal role in the HDL mediated-functional activities.Short peptides based on the amphiphilic alpha helix structure of apoA-I have been designed and aimed at imitating the function of apoA-I.The function and metabolism of these mimetic peptides depend on their amino acids component and sequence , and have been proved to exert protection in against cardiovascular disease , infection, inflammation and oxidative damage, metabolic syndrome and tumor.Clinical trials confirmed their benefits, but high cost put them out of the practical applications..
