Comparison of life quality between surgical castration and drug castration in advanced prostate cancer
10.3969/j.issn.1005-1678.2016.12.013
- VernacularTitle:手术去势与药物去势治疗晚期前列腺癌患者的生活质量比较
- Author:
Shenghua LI
;
Zijun CHEN
- Keywords:
surgical castration;
drug castration;
advanced prostate cancer;
quality of life
- From:
Chinese Journal of Biochemical Pharmaceutics
2016;36(12):53-56
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effects of surgical castration and intermittent androgen blockade (IAB) in patients with advanced prostate cancer.Methods 115 cases of advanced prostate cancer were selected including 48 cases with drug castration receiving IAB and 67 cases with surgical castration.Before the treatment, 6 months and 1 years after the treatment, the quality of life of the two groups was investigated by the quality of life questionnaire (EORTC QLQ-C30 +QLQ-PR25).Results Compared with before treatment, the general health status of the patients in the drug castration group and the surgical castration group were significantly improved (P<0.01), the whole body and the local pain were relieved (P<0.01) and the micturition symptoms were controlled ( P<0.01 ).The overall quality of life of drug castration group and surgical castration group were significantly decreased (P<0.05), and the degree of sexual function was particularly affected (P<0.01), but the body function of patients in drug castration group restored to a certain extent in drug castration group after 1 year’s treatment(P<0.01), while the quality of life in patients of surgical castration did not reverse.Conclusion Both of surgical castration and androgen deprivation therapy can reduce the quality of life of patients with advanced prostate cancer, but the adverse effects of drug treatment on the quality of life can be recovered in treatment intermission.
