The immune and pathological mechanism of the effect of monocyte chemotaxis protein -1 on the development of spinal tuberculosis
10.3969/j.issn.1005-1678.2016.12.043
- VernacularTitle:单核细胞趋化蛋白-1影响脊柱结核发病过程的免疫机制
- Author:
Rubing ZHANG
;
Yucheng BAO
- Keywords:
monocyte chemotactic protein-1;
spinal tuberculosis;
immune mechanism;
correlation study
- From:
Chinese Journal of Biochemical Pharmaceutics
2016;36(12):151-153
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the immune and pathological mechanism of the effect of monocyte chemotaxis protein -1 on the development of spinal tuberculosis.Methods A total of 1002 patients were enrolled in Tianjin Haihe Hospital from January 2011 to January 2016, which were included in the diagnostic criteria and exclusion criteria.Divided into 332 cases of spinal tuberculosis group(new spine tuberculosis subjects), 334 cases of pulmonary tuberculosis group( new pulmonary tuberculosis subjects), 336 cases of healthy group(healthy subjects), the serum concentration of monocyte chemotactic protein-1 ( MCP-1 ) was detected by enzyme-linked immunosorbent assay ( ELISA ) .To investigate the factors influencing the expression of MCP-1 and to analyze the correlation between serum MCP-1 concentration and spinal tuberculosis.Results Serum MCP-1 concentration in the body with the tuberculosis pathogenicity and sowing was gradually increasing.The concentration of MCP-1 in the spine tuberculosis group was significantly higher than that in thepulmonary tuberculosis group and the healthy group, the difference was statistically significant (P<0.05).There was no significant difference in serum MCP-1 concentrations between male and female patients in spine tuberculosis group , pulmonary tuberculosis group and healthy group.There was no significant difference in serum MCP-1 concentration between children and adults patients in spine tuberculosis group, pulmonary tuberculosis group and healthy group.Conclusion The serum concentration of MCP-1 in Spinal tuberculosis group is higher than pulmonary tuberculosis group and health group, and it shows an upward trend with the spread of tuberculosis.
