Expression of lysophosphatidic acid receptors in breast cancer and their significances
10.3760/cma.j.issn.1006-9801.2016.12.004
- VernacularTitle:溶血磷脂酸受体在乳腺癌中的表达及其意义
- Author:
Zhigang FAN
;
Kai SUN
;
Wanjun LI
;
Dong XIAO
;
Ming LIANG
;
Li WANG
;
Yongheng WANG
;
Jiansheng WANG
- Keywords:
Breast neoplasms;
Lysophospholipase receptor;
Clinicopathological features
- From:
Cancer Research and Clinic
2016;28(12):806-810
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the differential expression of lysophosphatidic acid receptor (LPAR) in breast cancer (BC), and its relationship with clinicopathological features of BC patients. Methods The qRT-PCR and immunohistochemical staining were used to detect the LPAR expression in 37 normal tissues, 55 benign disease tissues and 82 BC tissues, besides, the correlation of LPAR expression with clinicopathological data was also analyzed. Results The expression levels of LPAR2 and LPAR3 mRNA and protein in BC tissues were higher than those in normal benign tissues (all P<0.05). LPAR1 mRNA expression had no difference in three tissues (χ2 =1.908, P >0.05). LPAR1 expression was not associated with clinicopathological features in BC tissues (P>0.05). LPAR2 expression in postmenopausal patients was higher than that in premenopausal patients (χ2=4.821, P<0.05). LPAR3 expression was significantly associated with nodal metastasis, estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2) in BC tissues (all P<0.05). Conclusion LPAR in BC tissues has differential expression, which is associated with nodal metastasis, ER, PR and HER2.
