Meta-analysis of dosemetric comparision between helical tomotherapy and intensity-modulated radiotherapy for early-stage postoperative breast cancer
10.3760/cma.j.issn.1006-9801.2016.12.009
- VernacularTitle:早期乳腺癌术后螺旋断层放疗与调强放疗剂量学比较的 Meta 分析
- Author:
Qinling CUI
;
Yan SUN
;
Wen ZHONG
;
Yanzhi CHEN
;
Yuxia ZHAO
- Keywords:
Breast neoplasms;
Radiotherapy;
Helical tomotherapy;
Intensity-modulated radiotherapy;
Meta-analysis
- From:
Cancer Research and Clinic
2016;28(12):828-832
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the dosemetry between helical tomotherapy (HT) and intensity-modulated radiotherapy (IMRT) for early-stage postoperative breast cancer and provide more valuable evidences to the clinical researches. Methods Clinical trails of dosimetric comparing between HT and IMRT for early-stage breast cancer were obtained from PubMed, Embase, Sciencedirect, CNKI, VIP and Wanfang databases, evaluated and analyzed with the Cochrane Collaboration's RevMan 5.2 software. Results 10 studies were included with a total of 135 patients. Compared to IMRT plans, HT plans provided a significantly better conformity index (P<0.000 1), mean (P<0.000 01) and maximal dose (P=0.003) of the planning target volume (PTV). HT plans had a lower heart maximal dose (P=0.005), V20 (P=0.05), V30 (P=0.003), and ipsilateral lung maximal dose (P=0.003), V20 (P=0.02), as while as had a higher contralateral breast V5 (P=0.01), mean (P=0.05) and maximal dose (P<0.000 01). There was no significantly difference between HT and IMRT plans for homogeneity index of PTV, heart V5, V10, mean dose, ipsilateral lung V5, V10, V30, mean dose, contralateral breast V10, contralateral lung mean and maximal dose (all P >0.05). Conclusion Compared to IMRT plans, HT plans have the dosimetry superiority for early-stage breast cancer with significantly better coverage and dose conformity while maintaining lower doses to high risk organs.
