The clinical pathological characteristics of tumor-associated macrophages in esophageal squamous cell carcinoma
10.3969/j.issn.1671-8348.2016.36.012
- VernacularTitle:肿瘤相关巨噬细胞在食管鳞癌中的临床病理特征分析
- Author:
Wen FENG
;
Qingkai YU
;
Kuisheng CHEN
;
Miaomiao SUN
;
Jianbo ZHANG
- Keywords:
tumor-associated macrophages;
esophageal neoplasms;
carcinoma,squamous cell;
lymphatic metastasis
- From:
Chongqing Medicine
2016;45(36):5078-5080
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect the expression of tumor‐associated macrophages(TAM) in esophageal squamous cell carci‐noma ,and to study the clinical pathological characteristics of T AM in the esophageal squamous cell carcinoma .Methods Patients with esophageal squamous cell carcinoma who accepted operation were chosen as study subjects ,and tissue samples of esophagus were collected ,including 90 squamous cell carcinoma tissues ,20 paracancerous atypical hyperplasia and 20 normal mucosa tissues , and the expression of CD206 ,MCP‐1 were detected by immunohistochemisty .Results The positive expression of CD206 was sig‐nificantly increased in tissues of esophageal squamous cell carcinoma (P<0 .01) ,and it was positively correlated with clinical stage , invasion depth and lymph node metastasis in esophageal squamous cell carcinoma (P<0 .05) .The expression of MCP‐1 was signifi‐cantly increased in esophageal squamous carcinoma tissues (P<0 .05) ,and its positive expression was closely correlated with depth of invasion and lymph node metastasis in esophageal squamous cell carcinoma (P< 0 .05) .There was a positive relation between ATM infiltration quantity and the expression of MCP‐1(r=0 .617 ,P<0 .05) .Conclusion The positive expression of TAM was up‐regulated in esophageal squamous cell carcinoma tissues ,and its number was positively correlated with clinical stage ,invasion depth and lymph node metastasis .
