Overview of complement-targeted therapy
10.3969/j.issn.1005-1678.2016.12.002
- VernacularTitle:补体系统药物研究进展
- Author:
Ming JI
;
Liyuan WANG
;
Jing JIN
;
Xiaoguang CHEN
- Keywords:
complement system;
autoimmune diseases;
cancer;
infection;
complement inhibitor
- From:
Chinese Journal of Biochemical Pharmaceutics
2016;36(12):7-10
- CountryChina
- Language:Chinese
-
Abstract:
The complement system is a powerful effector arm of innate immunity, which have the roles in phagocytosis of foreign elements, solubilization of immune complexes, apoptotic cell clearance and enhance of humoral immune responses.Dysregulation of complement activity has been connected to various disease including infections, autoimmune diseases and cancers.These triggered a broad of candidates acting at complement activation are currently in clinical development.This review will provide an overview of complement system and related diseases , and update recent development in complement-targeted drug discovery.
