Recent advances of neoantigen in tumor therapy
10.3969/j.issn.1005-1678.2016.12.003
- VernacularTitle:新生抗原在肿瘤治疗中的研究进展
- Author:
Zhihao LIU
;
Shixin NI
;
Siyuan HE
;
Shuqing CHEN
- Keywords:
neoantigen;
accurate cellular immunotherapy;
antigenic epitope;
immune function
- From:
Chinese Journal of Biochemical Pharmaceutics
2016;36(12):11-14
- CountryChina
- Language:Chinese
-
Abstract:
As the research work went further and more detailed, a variety of new treatments compete to come out.However, it remains unclear that how the antigen works to distinguish cancer cells and normal cells.Neoantigen, which is located in the tumor cell surface of a specific antigen, its presence makes human immunotherapy into new areas which may make personalized treatment possible in the near future.Emerging data suggest that the identification of such newantigens is a major factor in clinical immunotherapy.They can form a biomarker in cancer immunotherapy to provide targets for a variety of therapeutic approaches to attack, which allows T cells to selectively enhance the immune response against this class of antigens.
