Compare anti-tumor activity and antioxidant activity of F.velutipes and A.auricula
10.3969/j.issn.1005-1678.2016.12.011
- VernacularTitle:金针菇与黑木耳醇提物的抗肿瘤和抗氧化作用比较
- Author:
Lu WANG
;
Mingyue LIU
;
Kunpeng XIE
;
Mingjie XIE
- Keywords:
F.velutipes;
A.auricula;
anti-tumor activity;
antioxidant activity
- From:
Chinese Journal of Biochemical Pharmaceutics
2016;36(12):46-48
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the anti-tumor activity and antioxidant activity of ethanol extracts of F.veluties and A.auricula.Methods Three human carcinoma cell lines, including MCF-7, HeLa and A375 were assessed by MTT assay to measure cell viability.The antioxidant activity was detected with a DPPH and RFAP assays.Results Two domestic fungus have different anti-tumor activity on the inhibition of MCF-7, HeLa and A375 cells at 25-400μg/mL concentration rage.F.velutipes was better than the A.auricula.The difference was statistically significant ( P<0.05 ).Compared with the control group, the inhibition of F.velutipes were 48.20%, 52.61%and 50.58%at the concentration of 400μg/mL, respectively (P<0.01).At the same concentration, the inhibition of A.auricula were 37.62%、50.21%and 41.59%, respectively (P<0.01).The ethanol extracts of two domestic fungus have significant antioxidant activity.F.velutipes was better than the A.auricula.The difference was statistically significant ( P<0.01 ).Compared with the control group, the scavenging radical capacities on DPPH of ethanol extracts of F.velutipes and A.auricula were 60.30%and 40.43%at the concentration of 1.6 mg/mL, respectively (P<0.01).At the same concentration FRAP value were 9.5 and 7.0 mmol/mL(P<0.01).Conclusion The F.velutipes and A.auricula both have strong anti-tumor and antioxidant activities, F.velutipes is better than A.auricula.
