Influence of beraprost on coagulation and neurological function in patients with acute cerebral infarction
10.3969/j.issn.1005-1678.2016.12.012
- VernacularTitle:贝前列素对急性脑梗死患者凝血功能和神经功能的影响
- Author:
Yang CHEN
;
Shuangxing HOU
;
Haihong ZHANG
;
Weizhong XIAO
;
Xiaobin CHEN
- Keywords:
beraprost;
acute cerebral infarction;
coagulation function;
neurological function
- From:
Chinese Journal of Biochemical Pharmaceutics
2016;36(12):49-52
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of blood coagulation function and nerve function of beraprost in the treatment of acute cerebral infarction.Methods 80 cases of acute cerebral infarction were randomly divided into 2 groups, 40 cases in the control group and 40 cases in the experiment group.The control group received routine treatment, the experiment group were treated with the same as the control group combined with beraprost.Changes of coagulation function and nerve function were compared pre-and post-treatment between two groups.Results Compared with pre-treatment, APTT, PT, Fib level, serum NGF level, Barthel score increased post-treatment of the two groups, D-D, serum NSE, S100b, NIHSS score decreased, compared with the control group, APTT, PT, Fib level, serum NGF level, Barthel score were higher in the experiment group, the total effective rate was higher than the control group, two D-D, serum NSE, S100β, NIHSS scores were lower than the control group, the differences were statistically significant (P<0.05).Conclusion Beraprost can reduce the high coagulation state in patients with acute cerebral infarction, improve the degree of neurological impairment, and has good clinical efficacy.
