Influence of intratracheal instillation of curosurf on right ventricular function in neonatal respiratory distress syndrome
10.3969/j.issn.1005-1678.2016.12.022
- VernacularTitle:固尔苏气管内滴注对新生儿呼吸窘迫综合征患儿右心功能的影响
- Author:
Jie RUAN
;
Suya ZHOU
;
Chao CHEN
- Keywords:
Curosurf;
right heart function;
intratracheal instillation;
neonatal respiratory distress syndrome
- From:
Chinese Journal of Biochemical Pharmaceutics
2016;36(12):81-83
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of intratracheal instillation of curosurf on neonatal respiratory distress syndrome ( NRDS ) in children with right ventricular function.Methods 52 patients with NRDS were retrospectively selected and divided into two groups according to different treatment.The patients in the conventional group were treated with nasal airway ventilation.Based on the conventional group, the curosurf group was taken with curosurf.26 cases were in each group.The blood gas index (PaCO2, PaO2, pH), inflammatory reaction (TNF-α, IL-10), SF of the two groups were compared, the complications and curative effect of the two groups before and after treatment were taken for statistics.Results There was no significant difference in pH value between the two groups at each time point.The PaO2 expression levels in the curosurf group at different time points after treatment were significantly lower than the conventional group (P<0.05).The levels of TNF-αand IL-10 in the curosurf group were more stable than those in the control group at different time points after treatment (P<0.05), and the degree of SF increasing at different time points were higher (P<0.05).The total effective rate 80.77% of the curosurf group was significantly higher than that of the conventional group 61.54%(P<0.05).The total complication rate 19.24% had no significant differences with the conventional group 23.08%.Conclusion Intratracheal instillation of CsA in the treatment of NRDS has the advantages of simple operation, little side effect, rapid recovery of blood gas index and inflammatory factors, so it is a feasible method for clinical treatment of NRDS.
