Neuroprotective effect of cerebrolysin in ophthalmology
10.3969/j.issn.1005-1678.2016.12.057
- VernacularTitle:脑蛋白水解物的视神经保护作用研究
- Author:
Mingqian ZHAO
;
Yongyao MAI
;
Baoqin LIN
;
Xueting LUO
;
Ting WANG
- Keywords:
cerebrolysin;
cell culture;
animal experiments;
clinical application;
optic nerve diseases
- From:
Chinese Journal of Biochemical Pharmaceutics
2016;36(12):196-199
- CountryChina
- Language:Chinese
-
Abstract:
Cerebrolysin is an aqueous mixture of amino acids extracted from porcine brain.Cerebrolysin, contains a variety of amino acids and low molecular weight peptides, are permeable to the blood-brain barrier and blood-ocular barrier and can directly act on neurons in the CNS.As amino acid-based neuroprotective reagents, cerebrolysin can improve the neuronal metabolism, promote synapse formation and induce neuronal differentiation, and thus elicit neuroprotective efffectagainst insults such as ischemia , neurotoxins and so on.Cerebrolysin is clinicly used to treat eye diseases such as traumatic eye damage, glaucoma, optic atrophy ect.This paper systematically summarizes the studies on preclinical and clinical application of cerebrolysin in ophthalmology.
