Correlation between blood pressure variability and cognitive impairment in patients with acute ischemic stroke
10.3760/cma.j.issn.1673-4165.2016.11.003
- VernacularTitle:急性缺血性卒中患者血压变异性与认知损害的相关性
- Author:
Shan GENG
;
Na LIU
;
Pin MENG
;
Niu JI
;
Yongan SUN
;
Yingda XU
;
Guanghui ZHANG
;
Xiaobing HE
;
Zenglin CAI
;
Bei WANG
;
Bei XU
;
Zaipo LI
;
Xiaoqin NIU
;
Yongjin ZHANG
;
Bingcao XU
;
Xinyu ZHOU
;
Mingli HE
- Keywords:
Stroke;
BrainIschemia;
Hypertension;
Blood Pressure;
Cognition Disorders;
Neuropsychological Tests;
Risk Factors
- From:
International Journal of Cerebrovascular Diseases
2016;24(11):992-997
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveToinvestigatethecorrelationbetweenbloodpressurevariabilityandcognitive impairment in ischemic stroke. Methods The inpatients with acute ischemic stroke were enroled. The demographic and clinical data were colected. The coefficient of variation of blood pressure within 7 days after onset w as calculated. Montreal Cognitive Assessment w as used to evaluate the cognitive function at three month after onset. Multivariate logistic regression analysis w as used to identify the relationship betw een the coefficient of variation of blood pressure w ithin 7 days and the cognitive impairment at 3 months after onset. Results A total of 708 patients w ith acute ischemic stroke w ere enrol ed in the study. At 3-month folow-up, 510 patients (72.0%) had cognitive impairment and 198 (28.0%) had normal cognitive function. The coefficient of variation for systolic blood pressure ( 8.3 ±1.2 vs.8.7 ±1.4; t= -3.299, P=0.001) and coefficient of variation for diastolic blood pressure ( 7.8 ±1.3 vs.8.0 ±1.5; t= -2.529, P=0.012) in the cognitive impairment group w ere significantly higher than those in the normal cognitive function group. With the first quintile as a reference, after adjusting other confounding factors, multivariate logistic regression analysis show ed that cognitive impairment at 3 months after onset w as significantly associated w ith coefficient of variation for systolic blood pressure. The odds ratios and 95 % confidence intervals for the 2-5 quantile groups w ere 2.33 (1.18-4.6), 2.31 (1.15-4.66), 2.70 (1.29-5.65), and 4.82 (1.92-12.1), respectively ( al P<0.05 ). Conclusion Systolic blood pressure variability in the acute phase of ischemic stroke is associated w ith cognitive impairment.
