Application of silicon in biomaterials：an increase in bioactivity but with no change in mechanical performance
10.3969/j.issn.2095-4344.2017.02.024
- VernacularTitle:硅在生物材料领域的应用：增加材料生物活性不影响其机械性能
- Author:
Shailin ZHANG
;
Xiangyu CHENG
;
Bin JI
- From:
Chinese Journal of Tissue Engineering Research
2017;21(2):296-302
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:Silicon plays an essential role in bone development and bioactive silicate glasses pioneered the current era of bioactive materials. Various biomaterials have been developed based on the biological function of silicon. OBJECTIVE:To explore the biological function of silicon and research process of silicon in biomaterials. METHODS: A computer-based retrieval of CNKI, PubMed, SpringerLink and Elsevier ScienceDirect databases was performed to search the relevant literatures concerning the biological function of silicon and its application in biomaterials. Al data were primarily screened to exclude repeated and irrelevant articles. Literatures about the application of silicon in biomaterials were included. RESULTS AND CONCLUSION:A total of 68 eligible English articles are enroled. Silicon plays important chemical and biological roles in bone. Silicon in the extracelular matrix interacts with glycosaminoglycans and proteoglycans during their synthesis and form ionic substitutions in the crystal lattice structure of hydroxyapatite. In addition, the dissolution products of bioactive glass (mainly silicic acid) expose significant influence on the molecular biology of osteoblasts in vitro, and can regulate the expressions of several genes including osteoblastic markers, cel cycle regulators and extracelular matrix proteins. Silicon has been proved to improve the bioactivity of numerous materials and do no harm to their mechanical properties and without cytotoxicity.
