The relationship between prothrombin fragment 1+2 and peripherally inserted central catheter ;associated thrombosis in cervical cancer patients
10.3760/cma.j.jssn.1673-4904.2017.02.004
- VernacularTitle:凝血酶原片段1+2与宫颈癌经外周静脉穿刺中心静脉置管患者静脉血栓形成的研究
- Author:
Na YUAN
;
Yinghua JIAO
;
Zhe WANG
;
Huanhuan GONG
;
Xiurong LU
;
Xianyu ZHANG
;
Huan MA
;
Jinqiu LI
;
Zhilin ZHANG
- Keywords:
Uterine cervical neoplasms;
Peripherally inserted central catheter;
Cathered related thrombosis;
Prothrombin fragment 1+2
- From:
Chinese Journal of Postgraduates of Medicine
2017;40(2):111-114
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between prothrombin fragment 1+2 (F1+2) and peripherally inserted central catheter (PICC) associated thrombosis in cervical cancer patients, and provide certain clinical basis of early prevention in peripherally inserted central catheter associated thrombosis in cervical cancer patients. Methods One hundred and forty cervical patients with PICC were enrolled in this study, and they were divided into thrombosis group (35 patients) and non-thrombosis group (105 patients). The level of F1+2 was examined using enzyme-linked immunoassay, and was analyzed according to the clinic features. Results The level of F1+2 was correlated with clinical stage (r = 0.640, P = 0.004);but was not correlated with age, type of tumor and concurrent radiochemotherapy (P>0.05). The level of F1+2 in thrombosis group was (520.343 ± 121.759) pmol/L, in non- thrombosis group was (388.361 ± 104.873) pmol/L, and there was significant difference (P =0.001). The multi-factors Logistic analysis showed that the level of F1+2 (OR=1.011, P=0.001) and age (OR = 21.025, P = 0.031) were independent risk factors for the PICC associated with thrombosis in cervical cancer. Conclusions The level of F1+2 is closely related with clinical stage and PICC associated thrombosis, and it is an independent risk factor for the PICC associated with thrombosis in cervical cancer.
