Risk factors analysis for colorectal cancer adjuvant chemotherapy induced leucopenia
10.3760/cma.j.jssn.1673-4904.2017.02.011
- VernacularTitle:结直肠癌根治术后辅助化疗白细胞降低的影响因素分析
- Author:
Hongmei DU
;
Shuo CAO
;
Meiyue TANG
;
Rong WU
- Keywords:
Colorectal neoplasms;
Leukopenia;
Risk factors;
Adjuvant chemotherapy;
Serum creatinine
- From:
Chinese Journal of Postgraduates of Medicine
2017;40(2):135-138
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the risk factors for colorectal cancer adjuvant chemotherapy induced leucopenia. Methods The basic clinical data of 108 patients with colorectal cancer who had received radical operation and adjuvant chemotherapy were retrospectively evaluated. The patients were divided into two groups: normal white blood cell group (39 patients) and leucopenia group (69 patients). The data were analyzed with SPSS 22.0 software, t test, χ2 test , univariate analysis and multifactor Logistic regression analysis, and analysis of variance to investigate the risk factors for colorectal cancer adjuvant chemotherapy induced leucopenia. Results Univariate analysis revealed that the female patients and the ones who received radiotherapy were more prone to leucopenia (P<0.01), while hypertension, the levels of white blood cell, neutrophil counting and serum creatinine before chemotherapy were protective factors for leucopenia (P<0.05 or<0.01). Multifactor Logistic regression analysis revealed that the level of serum creatinine before chemotherapy was an independent risk factor for leucopenia, OR = 0.950 (95% CI: 0.906- 0.996, P<0.05). The further analysis showed the lower the level of serum creatinine, the more severe the leucopenia would be (P = 0.04). Conclusions The level of serum creatinine before chemotherapy was an independent risk factor for colorectal cancer adjuvant chemotherapy induced leucopenia.
