Research progress of islet alpha cells in the pathogenesis and treatment of diabetes
10.3969/j.issn.1006-6187.2017.02.019
- VernacularTitle:胰岛α细胞在糖尿病发病及治疗领域中的研究进展
- Author:
Li GU
;
Mei ZHANG
- Keywords:
Islet alpha cell;
Diabetes mellitus;
Glucagon
- From:
Chinese Journal of Diabetes
2017;25(2):181-184
- CountryChina
- Language:Chinese
-
Abstract:
[Summary] Glucose homeostasis is precisely regulated by glucagon of pancreaticαcell and insulin ofβcell secretion.Diabetes is a chronic disease characterized by insulin deficiency or insulin resistance (IR). Absolute or relative excess of glucagon secretion may play an important role in the development of diabetes.Previously more studies on the functions of islet βcells were reported,but less on islet αcells. There are a variety of factors involved in the regulation of glucagon secretion,such as nutrients,endocrine hormones and neurotransmitters. High fasting and postprandial blood glucose in patients with diabetes are associated with increased glucagon.Isletαcell dysfunction is closely related to the development of diabetes and the ability of responding to hypoglycemia.Further studies of α cell function and its role on the development of diabetes could provide insight into the treatment of diabetes.
