Clinical significance of PRL-3 expression in sinonasal squamous cell cancer cells

VernacularTitle:鼻腔鼻窦鳞状细胞癌细胞中PRL-3表达的临床意义
Author: Honglue LU ; Guiqin MA ; Zhuoli YUE ; Fei KANG
Keywords: nasal cavity; paranasal sinus; carcinoma,squamous cell; regenerative liver phosphatase-3
From: Chongqing Medicine 2017;46(1):81-83
CountryChina
Language:Chinese
Abstract: Objective To investigate the clinical significance of PRL-3 expression in sinonasal squamous cell cancer(SNSCC).Meth-ods The immunohistochemical method and RT-PCR were adopted to detect the PRL-3 protein expression level in 62 cases of SNSCC tissue (SNSCC group),30 cases of nasal polyps(NP group)tissue and 25 cases of normal nasal mucosa tissue(control group).The obtained results were compared.Results Both in the protein level and gene level detection,the expression of PRL-3 in the SNSCC group was higher than that in the NP group and control group,the difference was statistically significant (P <0.05).The expression of PRL-3 had no significant differences among different ages and between different genders(P >0.05),but with TNM stage increasing,differentiation degree decreasing and complicating lymph node metastasis,the expression of PRL-3 was significantly increased(P <0.05).Conclusion The PRL-3 expression can serve as good reference for the proliferation activity of SNSCC,its expressing intensity can obviously reflect the SNSCC cell proliferation activity,PRL-3 probably is an independent prognostic index of SNSCC,indicating poor prognosis.