Advanced oxidation protein products in predicting the progression of diabetic retinopathy in patients with type 2 diabetes mellitus

VernacularTitle:晚期氧化蛋白产物对2型糖尿病视网膜病变进展的预测价值
Author: Qianqian SHI ; Yan GAO ; Guangli SUN
Keywords: Advanced oxidation protein products(AOPP); Diabetic retinopathy(DR); Biomarker
From: Chinese Journal of Diabetes 2017;25(2):116-120
CountryChina
Language:Chinese
Abstract: Objective To explore the ability of advanced oxidation protein products (AOPP)in predicting the progression of diabetic retinopathy (DR)in patients with type 2 diabetes mellitus (T2DM). Methods 363 T2DM patients were enrolled in this prospective cohort study. According to the quartile points of baseline AOPP level,patients were divided into four groups (Q1,Q2,Q3 and Q4 ). The progression rate of DR was calculated according to the changes of non-mydriatic fundus photography after a 5-year follow-up. Results With the increase of baseline AOPP level,the rate of progression of DR increased (19.51% vs 28.42% vs 37.36% vs 47.37%,P <0.01). Logistic regression analysis showed that baseline level of AOPP was an independent risk factor for the progression of DR (OR=1.833,95%CI:1.573~1.982,P<0.05).Area under the curve of AOPP in predicting DR is 0.883 (95% CI:0.842~0.924)with the sensitivity 86.1% and specificity 91.9%. Conclusion AOPP may be one of the biomarkers for the prediction of type 2 diabetic retinopathy progression.