Clinicopathological analysis of 3 cases of trichoblastoma
10.3969/j.issn.1671-8348.2017.01.015
- VernacularTitle:3例毛母细胞瘤临床病理分析
- Author:
Guangye CHEN
;
Chun ZHANG
;
Hongjing ZHU
;
Hongli ZHANG
;
Jiajun LIU
;
Qing YANG
- Keywords:
trichoblastoma;
basal-like cells;
palisade arrangement;
papillary mesenchymal bodies;
basal cell carcinomas;
im-munohistochemistry
- From:
Chongqing Medicine
2017;46(1):68-71
- CountryChina
- Language:Chinese
-
Abstract:
Objective To summarize and study the clinicopathologic features,diagnosis and differential diagnosis of tricho-blastoma (TB).Methods The clinicopathological characteristics,histomorphology features and immunophenotype features of TB and differential diagnosis with multiple diseases in 3 cases of TB were retrospectively analyzed;moreover,5 cases of basal cell carci-noma were selected and performed the immunophenotype detection,which focused on the differential diagnosis with TB.Results The masses in 3 cases were located under the skin without connecting with the epidermis and were composed of basal-like cells with palisade arrangement of peripheral cells.The case 1 showed unequal-sized multiple cyst cavities and pigment deposition and was di-agnosed as pigmented TB.The papillary mesenchymal bodies were found in case 2,which was diagnosed as TB.The basal cells of tumor in case 3 distributed as palisade arrangement and formed the wave structure,which was diagnosed as rippled-pattern TB.AR in 3 cases and Bcl-2 in 2 cases were negative expression,CK20 in 1 case was sporadically positive,CD10 stroma and papillary struc-ture in 3 cases were positive,paliform-like arrange tumor cells CD10 around basal cell carcinomas in 5 cases were positive,AR in 4 cases was positive,Bcl-2 in 3 cases was positive and CK20 in 5 cases was negative.Conclusion TB is a benign tumor derived from the hair follicle germinal epithelium with a good prognosis after complete resection and the differential diagnosis focuses on basal cell carcinomas.
