Early-stage clinical characteristics and HPA axis alterations in first-episode and untreated the major de-pressive disorder patients with suicide
10.3969/j.issn.1002-0152.2016.10.005
- VernacularTitle:未用药抑郁症自杀者的临床特征与HPA轴功能分析
- Author:
Haibing ZHU
;
Danfeng WANG
;
Yun GAO
;
Ting ZHOU
;
Zixing WU
;
Juan QI
- Keywords:
Major depressive disorder;
Suicide;
Hypothalamic-pituitary-adrenal (HPA) axis
- From:
Chinese Journal of Nervous and Mental Diseases
2016;42(10):596-600
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare early-stage clinical features and hypothalamic-pituitary-adrenal (HPA) axis neuroendocrine function in first-episode and untreated major depressive disorders with suicide and without suicide. Methods Untreated patients who had a diagnosis as major depression according to ICD-10 were allocated to suicide with major depressive disorder group or non-suicide with major depressive disorder group according to whether the pa?tients had suicidal ideation or behaviours. Patients were assessed before treatment using the 17-item Hamilton Depres?sion Scale (HAMD-17), the Hamilton Anxiety Scale (HAMA), the Yale-Brown Obsessive Compulsive Scale (YBOCS) and the suicide assessment scale. The cortisol (CORT) and adrenocorticotropic hormone (ACTH) levels in serum were measured using a chemiluminescence immunoassay. Results There was no significant difference in demographic data be?tween the two groups (P>0.05). In early-stage clinical features, there were significant differences in changes of sexual ac? tivity and feeling of despair (P<0.05). HAMD total scores were significantly higher in the suicide group (P<0.01), whereas HAMA total scores and Y-BOCS total scores were not significantly different between the two groups (P>0.05). There were no significant differences in CORT or ACTH levels between two groups (P>0.05). There were no significant correlation of suicidal scores with early-stage clinical features, symptom scales scores, CORT or ACTH levels (P>0.05). Conclusion De?creased sexual desire and feeling of despair are more severe in depressed patients with suicide than those without. There is no correlation of early-stage clinical features or HPA axis functions with suicide in patients with depression.
