RhoGDI2 expression and clinical significance in colorectal cancer
10.3969/j.issn.1000-484X.2017.01.022
- VernacularTitle:RhoGDI2在结直肠癌中的表达及临床意义
- Author:
Siqi LIU
;
Lijun MA
;
Hongli YAN
;
Wenrui WANG
;
Zhenjing JIN
- Keywords:
RhoGDI2;
Colorectal cancer;
Metastasis
- From:
Chinese Journal of Immunology
2017;33(1):108-111
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the expression and clinical significance of RhoGDI2 in colorectal cancer. Methods:Immuno-histochemistry was used to identify RhoGDI2 expression in clinical samples of colorectal cancer tissues,para-tumorous tissues and lymph node metastasis tissues. The relationships between CRC clinical factors and survival were analyzed. Results: RhoGDI2 expression contributed positively with tumor progression and metastasis in clinical tissues. It was associated with the stage of the tumor,lymph node metastasis, remote metastasis, venous invasion and vessel invasion. Patients with higher RhoGDI2 expression had poorer overall survival. Conclusion:RhoGDI2 showed high expression in colorectal cancer and it was associated with the stage of the tumor,lymph node metastasis,remote metastasis, venous invasion and vessel invasion. Patients with higher RhoGDI2 expression had poorer overall survival.
