Correlation between blood glucose variability and poor prognosis in diabetic patients with acute stroke
10.3969/j.issn.1006-6187.2017.01.012
- VernacularTitle:糖尿病合并急性期脑卒中患者血糖变异性与短期不良预后的相关性
- Author:
Lu YIN
- Keywords:
Diabetes mellitus;
Acute stroke;
Blood glucose variability;
Prognosis
- From:
Chinese Journal of Diabetes
2017;25(1):53-57
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between blood glucose variability and poor prognosis in diabetes patients with acute stroke. Methods A total of 1 5 5 diabetes patients with acute stroke were divided into glucose variability group(n= 92,GluSD≥1. 4 mmol/L)and non-glucose variability group(n= 63,GluSD<1. 4 mmol/L)according to the GluSD levels. Then,the subjects in glucose variability group were divided into three subgroups according to GluSD levels:the lowest tertile group (GluSD 1. 42~1. 87 mmol/L),the middle tertile group(GluSD 1. 43~2. 32 mmol/L)and the highest tertile group(GluSD 2. 33~2. 87 mmol/L). All patients accepted 72 h CGM after admission. NIHSS score, MoCA scale and Barthel index were used to assess short-term prognosis. Non-conditional logistic regression analysis was used to analyze the risk factors for poor prognosis. Results The levels of FPG [(8. 49± 1. 71 )vs (7. 33 ± 1. 58 )mmol/L],HbA1 c [(8. 61 ± 0. 55 )% vs (7. 14 ± 0. 43 )%]GluAve, GluMAGE,GluGLI and GluCV were higher in glucose variability group than in non-glucose variability group(P<0. 05 or P<0. 01 ). GluAve,GluMAGE,GluGLI and GluCV were higher in the highest tertile group than in the lowest tertile group (P<0. 05 ). With the increase of GluSD level,NIHSS score increased,MoCA score and Barthel index reduced (P<0. 05 ). Multivariate logistic regression analysis showed that age,HbA1 c,GluAve,GluCV and NIHSS score were risk factors for poor prognosis(P<0. 05 or P<0. 01). Conclusion Blood glucose variability is related to poor prognosis in diabetes patients with acute stroke,suggesting that reducing blood glucose fluctuations may be more beneficial to improve outcomes in the treatment of hypoglycemia.
