Effect of Aging on Related Biological Activity Factors in Gastric Fundic Mucosa in Beagle Dogs
10.3969/j.issn.1008-7125.2017.02.010
- VernacularTitle:比格犬胃底黏膜相关生物活性因子的增龄变化
- Author:
Xiaowen LI
;
Songbai ZHENG
;
Xiaoli ZHANG
;
Fei LIU
- Keywords:
Gastric Fundus;
Aging;
Calcitonin Gene-Related Peptide;
Cyclooxygenase 1;
Cyclooxygenase 2
- From:
Chinese Journal of Gastroenterology
2017;22(2):106-108
- CountryChina
- Language:Chinese
-
Abstract:
Recent studies showed that gastric mucosa was more susceptible to injury by invasion factors with aging, however,the studies were mainly on gastric antral mucosa,fundic mucosa was rarely studied.Aims:To investigate the effect of aging on related biological activity factors in gastric fundic mucosa in beagle dogs.Methods:Nineteen beagle dogs were assigned into younger group (aged 1-5 years),junior elderly group (aged 6-8 years)and senior elderly group (aged≥9 years).The contents of MDA,LPO,MPO in gastric fundic mucosa were determined by TBA method.The contents of PTEN,TE,survivin,caspase-3,caspase-9,ZO-1,CGRP,VEGF,COX-1 and COX-2 were assessed by ELISA.Results:Compared with younger group and junior elderly group,contents of MDA,LPO,MPO,PTEN,TE,ZO-1 ,CGRP,VEGF, COX-1 and COX-2 were significantly increased in senior elderly group (P<0.05),no significant differences in contents of caspase-3 and caspase-9 were found among the three groups (P>0.05 ).The content of survivin in junior elderly group and senior elderly group was significantly decreased when compared with younger group (P =0.000 ).Conclusions:Disadvantaging changes of biological activity factors are found in gastric fundic mucosa in elderly beagles dogs,however, gastric mucosal blood flow, mucosa regeneration and epithelial tight junction related biological activity factors are significantly increased in senior elderly beagle dogs,which may be a phenomenon of degeneration-compensation.
