Role of Farnesoid X Receptor in Treatment of Primary Biliary Cholangitis
10.3969/j.issn.1008-7125.2017.02.011
- VernacularTitle:法尼醇X受体在原发性胆汁性胆管炎治疗中的作用
- Author:
Jian ZHAO
;
Wei LI
;
Dingkang YAO
- Keywords:
Primary Biliary Cholangitis;
Farnesoid X Receptor;
Obeticholic Acid;
Cholic Acid;
Therapy
- From:
Chinese Journal of Gastroenterology
2017;22(2):109-111
- CountryChina
- Language:Chinese
-
Abstract:
Primary biliary cholangitis (PBC)is a commonly seen cholestatic liver disease.Currently,ursodeoxy-cholic acid (UDCA)is the only drug approved for the effective treatment of PBC.However,up to 40% of PBC patients had poor response to UDCA.Farnesoid X receptor (FXR)can inhibit the synthesis of bile acid,regulating the transport of bile acid and playing a role in anti-hepatic fibrosis.This article reviewed the role of FXR in treatment of PBC.
