Progress in Study on Relationship between Autoantigens of PAB and Crohn 's Disease
10.3969/j.issn.1008-7125.2017.02.012
- VernacularTitle:PAB靶抗原与克罗恩病关系的研究进展
- Author:
Lihui ZHANG
;
Chengdang WANG
- Keywords:
Crohn Disease;
Antibodies Against Exocrine Pancreas;
GP2;
CUZD1;
Diagnosis
- From:
Chinese Journal of Gastroenterology
2017;22(2):112-114
- CountryChina
- Language:Chinese
-
Abstract:
It is reported that zymogen granule membrane glycoprotein 2 (GP2 )and CUB and zona pellucida-like domain-containing protein 1 (CUZD1 )are the major autoantigens of autoantibodies against exocrine pancreas (PAB).GP2 is mainly expressed in the pancreatic acinar cell and M cells in small intestine follicle-associated epithelium,and CUZD1 is mainly expressed in uterus,ovary and pancreatic acinar cell.PAB is a relatively specific antibody for Crohn's disease (CD).The article reviewed the progress in study on autoantigens of PAB in CD.
