Regulatory mechanisms of ubiquitin system in Mycobacterium tuberculosis-host interactions
10.3969/j.issn.1000-484X.2017.02.001
- VernacularTitle:泛素系统在结核分枝杆菌与宿主相互作用中的调控机制研究进展
- Author:
Qiyao CHAI
;
Cuihua LIU
- Keywords:
Ubiquitin system;
Mycobacterium tuberculosis;
Macrophage;
Innate immunity;
Signaling pathway;
Effector proteins
- From:
Chinese Journal of Immunology
2017;33(2):161-169
- CountryChina
- Language:Chinese
-
Abstract:
Mycobacterium tuberculosis ( Mtb) is an extremely successful intracellular bacterial pathogen that engages multiple strategies to escape host immune surveillance,so as to survive within host macrophages for long period. Upon the invasion of pathogenic bacteria,the host ubiquitin system plays a critical role in activating the host innate immune responses and associated signaling pathways such as inflammatory and immune responses, autophagy, phagosome maturation and cell death, etc. On the other hand, recent studies have demonstrated that intracellular pathogenic bacteria such as Mtb can secrete a variety of effector proteins into host cells to hijack or co-opt the ubiquitin system to suppress host immune responses. Those pathogen-host interacting interfaces could provide potential novel targets for the development of anti-tuberculosis drugs.
