Changes of sTim-3/HMGB1 and Spot forming cells of TGF-β secreting from peripheral blood mononuclear cell in patients infected with brucella
10.3969/j.issn.1000-484X.2017.02.017
- VernacularTitle:布鲁氏菌病患者血清 sTim-3/HMGB1水平及外周血单个核细胞产生TGF-β斑点形成细胞的变化
- Author:
Pan PANG
;
Yuejie ZHU
;
Jinwei HU
;
Bin JIA
;
Fengbo ZHANG
;
Jianbing DING
- Keywords:
sTim-3;
HMGB1;
TGF-β;
Brucellosis
- From:
Chinese Journal of Immunology
2017;33(2):247-251
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the changes of sTim-3,HMGB1 and TGF-β in the brucellosis patients and to analyse the relationship between the changes of these molecules and brucella infection. Methods:28 cases of brucellosis patient untreated and 28 healthy control cases in the age and gender matched with brucellosis cases were collected. The serum levels of sTim-3 and HMGB1 were detected by ELISA,and the levels of Spot forming cells secreting TGF-β were measured by ELISPOT in patients and healthy control group. Results: Compared with healthy controls, sTim-3/HMGB1 expression levels and Spot forming cells secreting TGF-β were significantly increased in the brucellosis patients ( P<0. 01 ) . The changes of Spot forming cells secreting TGF-β were positively correlated with the levels of HMGB1 (P<0. 05). Conclusion:The serum levels of sTim-3/HMGB1 and Spot forming cells of secreting TGF-β from peripheral blood mononuclear cell are significantly increased in the brucellosis patients. Those molecules may be involved in the process of brucella infection and may play a significant role in the immune escape of patients infected with brucella.