Effect of compound flavonoids on atherosclerosis in ApoE -/- mice
10.3969/j.issn.1001-1978.2017.02.008
- VernacularTitle:复方总黄酮对 ApoE 基因敲除小鼠动脉粥样硬化的影响
- Author:
Xiaoqing ZHU
;
Jie YANG
;
Juan SHAO
;
Chao LIU
;
Jiliang WU
- Keywords:
ApoE knockout mice;
atherosclerosis;
compound flavonoids;
lipid metabolism;
plaque;
in-flammation
- From:
Chinese Pharmacological Bulletin
2017;33(2):180-184
- CountryChina
- Language:Chinese
-
Abstract:
Aim To investigate the protective effect of compound total flavonoids on atherosclerosis in ApoE -/- knockout mice.Methods Seven-week old C57BL/6 mice considered of the normal group (n =1 5 );seven-week old ApoE -/- mice were fed with high-fat diet and were assigned randomly into 5 groups:model group,simvastatin group,the low com-pound flavonoids group,the middle compound fla-vonoids group and the high compound flavonoids group.After 1 6 weeks,mice serum and aortas were harvested.The formation of atherosclerotic plaque was analyzed by HE staining,The serum level of lipids pro-files and superoxide dismutase (SOD )were deter-rnined.The levels of IL-1 βand NF-κB in serum were detected by ELISA assay.Results Area of atheroscle-rotic lesion was significantly less in the compound fla-vones group than in model.The level of TC,TG,LDL-C,IL-1 β,NF-κB in serum of the compound flavonoids group were decreased significantly,while SOD and HDL-C increased significantly compared with the mod-el group,and the difference was significant (P <0.05).Conclusion The compound flavonoids have a good protective effect on early atherosclerosis in mice, which may be due to its alleviating effects on hyperlipi-demia and inflammation and oxidation.
