Regulatory necrosis:a novel way to recognize and prevent injury-relevant diseases
10.3969/j.issn.1001-1978.2017.02.002
- VernacularTitle:调节性坏死：认识和防治损伤相关性疾病的新途径
- Author:
Shijing WANG
;
Jun PENG
- Keywords:
regulated necrosis;
programmed necrosis;
ferropto-sis;
parthanatos;
cyclophilin D;
cyclosporin;
necroptosis
- From:
Chinese Pharmacological Bulletin
2017;33(2):153-157
- CountryChina
- Language:Chinese
-
Abstract:
Necrosis is also tightly controlled by signaling path-ways,thus it is called as regulated necrosis,which includes ne-croptosis,ferroptosis,parthanatos and CypD-mediated necrosis. It has been shown that regulated necrosis is closely related to the occurrence,development and prognosis of injury-relevant disea-ses such as myocardial infarction,stroke,neurodegenerative dis-eases.It will be significant for prevention and therapy of injury-relevant diseases to clarify the signal transductions and regulatory mechanisms for the regulated necrosis.
