Influence ofFurong-Tongmai capsules on myocardial expression of LN and CollagenⅢ in diabetes mellitus rats
10.3760/cma.j.issn.1673-4246.2017.02.012
- VernacularTitle:复荣通脉胶囊对糖尿病大鼠心肌Ⅲ型胶原蛋白及纤连蛋白表达的影响
- Author:
Lixin WANG
;
Yuansong WANG
;
Fengsheng TIAN
;
Ronggang CUI
;
Yang SU
;
Xiue CHI
;
Yun BIAN
- Keywords:
Diabetes;
Myocardium;
Fibronectins;
Collagen;
Furong-Tongmai capsules;
Rats
- From:
International Journal of Traditional Chinese Medicine
2017;39(2):140-143
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the the influence ofFurong-Tongmai capsules on myocardial expression of LN and CollagenⅢ in diabetes mellitus (DM) rats.Methods A total of 60 rats were randomly divided into the control group, the model group, the low-, middle- high-dosageFurong-Tongmai capsules group (n=10). The low-, middle-high-dosageFurong-Tongmai group was given 1.4, 0.7, 2.8 g/(kg body weight) Furong-Tongmai capsules. The other two groups were given the same dose of purified water. After 8 weeks treatment, the myocardial was taken to make pathology slice with SP immunohistochemistry staining. The expression of LN and CollagenⅢ were detected.Results Compared with model group, the expression of LN (0.67% ± 0.04%,0.65% ± 0.09%vs. 1.08% ± 0.13%) and CollagenⅢ (0.67% ± 0.15%, 0.69% ± 0.13%vs. 1.17% ± 0.12%) in the middle-high-dosageFurong-Tongmai groups significantly decreased (P<0.05). However, there were no statistical differences between the low-, middle- high-dosageFurong-Tongmai groups and the model group (P>0.05).Conclusions TheFurong-Tongmai capsules could inhibit the expression of LN and CollagenⅢ in DM rats.
