Role of tumor necrosis factor -alpha -induced protein 8 -like 2 in development and progression of liver and gastro-intestinal tumors

VernacularTitle:肿瘤坏死因子α诱导蛋白8样分子2在肝脏及胃肠道肿瘤发生发展中的作用
Author: Li KONG ; Meng JIN ; Suxian ZHAO
Keywords: liver neoplasms; stomach neoplasms; intestinal neoplasms; tumor necrosis factor -alpha -induced protein 8 -like 2; review
From: Journal of Clinical Hepatology 2017;33(1):175-179
CountryChina
Language:Chinese
Abstract: Liver and gastrointestinal tumors greatly threaten human health and have poor therapeutic outcomes and prognosis.Tumor necrosis factor -alpha -induced protein 8 -like 2 (TIPE2)can negatively regulate innate immunity and adaptive immunity and maintain immune ho-meostasis.Recent studies have found that TIPE2 can affect various signaling pathways and thus exerts an inhibitory effect on the development and progression of tumors.This article briefly introduces the structure and function of TIPE2 and its regulatory effect on tumor -related sig-naling pathways such as Ras,Ral,and Rac and downstream molecules,as well as the role of TIPE2 in liver and gastrointestinal tumors,re-lated signaling pathways,and research advances.