Long-term therapeutic response of two therapies for idiopathic thrombocytopenic purpura
10.3969/j.issn.1673-4130.2017.02.017
- VernacularTitle:2种方法在治疗特发性血小板减少性紫癜长期疗效的对比
- Author:
Fangrong ZHENG
;
Qianhong JIAN
;
Peiyuan TANG
;
Junfeng SONG
;
Kele QIN
;
Xiong YAN
- Keywords:
splenectomy;
idiopathic thrombocytopenic purpura;
laparoscopy;
postsplenic complications;
relapse-free survival rate
- From:
International Journal of Laboratory Medicine
2017;38(2):191-193
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the perioperative outcomes and long-term therapeutic response of laparoscopic splenectomy versus open splenectomy for idiopathic thrombocytopenic purpura.Methods A retrospective analysis of 124 patients who under-went splenectomy(68 LS and 56 OS)for ITP between January 2011 and January 2015 was conducted.Results Patients undergoing LS were found to require a longer operative time(P <0.05 )but had reduced hospital stay,lower intra-operative blood loss(P <0.05),less postoperative pain,earlier drain removal,and decreased incidence of complications(P <0.05).Conversion to OS was re-quired in 4 patients for excessive loss of blood(5.8%).Deep venous thrombosis(DVT)was observed in 1 patients after OS.One pa-tient died from pneumonia after LS.Mean follow-up of (33±11.8)months was performed in LS group and of (32±12.9)months in OS group.50 patients(73.5%)in LS group and 43(76.7%)in OS group reached sustained complete haematological response(P >0.05).Kaplan-Meier analysis showed that there was no significant difference in the relapse-free survival rate between the groups (P =0.679).Conclusion Compared with open splenectomy,laparoscopic splenectomy for patients with ITP has similar long-term therapeutic response,but it has advantages of minimally invasiveness.
