Effects of dexmedetomidine on early postoperative cognitive function after non-cardiac surgery in elderly patients:a meta-analysis
- VernacularTitle:右美托咪定对全身麻醉下行非心脏手术老年患者术后早期认知功能影响的 Meta 分析
- Author:
Yi WANG
;
Huaichang WENG
;
Xiaoju JIN
;
Liu YANG
- Keywords:
Dexmedetomidine;
Cognitive-function;
Elderly patients;
Meta-analysis
- From:
The Journal of Clinical Anesthesiology
2017;33(1):45-51
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effects of dexmedetomidine on postoperative cognitive function after non-cardiac surgery in elderly patients by meta-analysis.Methods We searched Co-chrane Library,MEDLINE,EMbase,Ovid,Springer,China Biology Medicine,CNKI,VIP and WanFang Data for controlled clinical trials.All randomized controlled trials (RCT)that meet their standards of dexmedetomidine on postoperative cognitive function after non-cardiac surgery in elderly patients were collected. The meta-analysis was performed by Review Manager 5.3. Results Twenty-two trials with 1 713 patients were included in this meta-analysis.The results of me-ta-analysis showed that:Mini-mental state examination (MMSE)MD=2.99,95%CI (2.25,3.74) one day before operation,MD=1.66,95%CI (0.68,2.64)three days after operation,MD=1.52, 95%CI (0.55,2.49)seven days after operation,respectively (P <0.05);Perioperative dexmedeto-midine treatment was significantly associated with better neurocognitive performance in comparison with saline.Compared with normal saline group,the serum concerntrations of neuron-specificenolase, S100β protein, TNF-α and IL-6 were significantly decreased in dexmedetomidine group. Conclusion The present meta-analysis indicates that dexmedetomidine shows superiority over placebo in early postoperative neurocognitive function after non-cardiac surgery in elderly patients.
