The effects of ACTH and Huaiqihuang on the treatment of recurrence nephrotic syndrome in children
10.11958/20160184
- VernacularTitle:ACTH和槐杞黄治疗频复发肾病综合征患儿的疗效观察
- Author:
Wenhong WANG
;
Bili ZHANG
;
Yan LIU
;
Yan LIU
;
Linsheng ZHAO
;
Lixiao YANG
- Keywords:
nephrotic syndrome;
adrenal cortex hormones;
glucocorticoids;
hydrocortisone;
cortisol;
Huaiqihuang;
hypothalamic pituitary adrenal axis
- From:
Tianjin Medical Journal
2017;45(1):54-57
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects and safety of adrenocorticotropic hormone (ACTH) combined with Huaiqihuang on frequent relapse nephrotic syndrome (FRNS) in children. Methods Fifty-five child patients with FRNS were divided into control group, which was given glucocorticoid (GC) to maintain the treatment (group A, n=10), Huaiqihuang group (group B, n=17), ACTH group (group C, n=14) and ACTH combined with Huaiqihuang group (combined treatment group, group D, n=14). Continuous treatment was for 12 months. The GC treatment doses, the levels of basal secretion of adrenal cortex and adrenal cortex reserve were recorded at 6-month and 12-month respectively. And the recurrence rate and adverse reactions were observed in four groups. Results After 6-month treatment, the doses of GC were significantly lower in group C and group D than those in group A and group B (P<0.05). The levels of basal secretion of adrenal cortex were increased in turn in group A~D (P<0.05). After 12-month treatment, the doses of GC were significantly decreased in group C and group D than those in group A and group B, while the level of basal secretion of adrenal cortex and adrenal cortex reserve were increased (P<0.05). There were no significant differences in the doses of GC between group C and group D (P>0.05). After treatment for 6 months and 12 months, the recurrence rates of nephrotic syndrome were significantly lower in group C and group D than those of group A and group B (P<0.05). Conclusion The simple application of ACTH and the combination of Huaiqihuang can relieve the inhibition of long-term using GC on hypothalamic pituitary adrenal axis in FRNS patients.
