Cyclophosphamide-induced Posterior Reversible Encephalopathy Syndrome in a Patient with Lupus Nephritis.
10.4078/jrd.2013.20.2.103
- Author:
Chang Hoon LEE
1
;
Yu Min LEE
;
Seon Ho AHN
;
Dae Woong RYU
;
Ju Hung SONG
;
Myeung Su LEE
Author Information
1. Department of Internal Medicine, Wonkwang University School of Medicine, Iksan, Korea. ckhlms@wku.ac.kr
- Publication Type:Case Report
- Keywords:
Posterior reversible encephalopathy syndrome;
Systemic lupus erythematosus;
Cyclophosphamide
- MeSH:
Autoimmune Diseases;
Blood Pressure;
Consciousness;
Cyclophosphamide;
Eclampsia;
Edema;
Female;
Humans;
Hypertension;
Korea;
Lupus Erythematosus, Systemic;
Lupus Nephritis;
Magnetic Resonance Imaging;
Nephritis;
Neuroimaging;
Pregnancy;
Seizures
- From:Journal of Rheumatic Diseases
2013;20(2):103-107
- CountryRepublic of Korea
- Language:English
-
Abstract:
Posterior reversible encephalopathy syndrome (PRES) is a neurologic condition characterized by vasogenic edema on neuroimaging and is associated with the setting of severe hypertension, eclampsia, autoimmune disease, malignancy, and immunosuppressive drugs. We report on a 42 year-old female systemic lupus erythematous patient who presented altered consciousness, seizure, and visual disturbance after cyclophosphamide pulse therapy. Magnetic resonance imaging (MRI) showed multi-focal high signal intensity lesions in the parieto-occipital cortex bilaterally and in the subcortical white matter. Her condition was improved and her MRI lesions were resolved after aggressive blood pressure control and high-dose steroid treatment. It is possibly the first reported case of PRES in a patient with lupus, treated with cyclophosphamide pulse therapy during a nephritis flare in Korea.
