Impact of Cardiac Resynchronization Therapy on Ventricular Remodeling in Patients With III°Atrio-ventricular Block Combining Systolic Dysfunction
10.3969/j.issn.1000-3614.2017.01.013
- VernacularTitle:心脏再同步化治疗对合并左心室收缩功能不全的三度房室传导阻滞患者左心室重构的影响
- Author:
Cuiping XIE
;
Kangyu CHEN
;
Ji YAN
;
Jian XU
;
Hao SU
;
Fei YU
;
Hongjun ZHU
;
Wei SHEN
;
Chunsheng AN
;
Dongmei YANG
- Keywords:
Cardiac resynchronization therapy;
Atrio-ventricular block;
Ventricular remodeling
- From:
Chinese Circulation Journal
2017;32(1):54-57
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To observe the impact of cardiac resynchronization therapy (CRT) on ventricular remodeling in patients with III°atrio-ventricular block (AVB) combining systolic dysfunction.
Methods: A total of 49 III °AVB patients received CRT in our hospital from 2009-01 to 2014-10 were studied. Echocardiography was conducted at pre-operation and 6, 12 months post-operation to measure left ventricular ejection fraction (LVEF), left ventricular end-systolic volume (LVESV), left ventricular end-diastolic volume (LVEDV), left ventricular end-diastolic diameter (LVEDD), left ventricular end-systolic diameter (LVESD) and mitral regurgitation (MR) grade in order to observe the changes of cardiac structure and function in relevant patients.
Results: Compared with pre-operative condition, at 6 months post-operation, LVEF was increased (4.92±5.24)%and at 12 months post-operation, it was further increased (5.02±6.52)%, both P<0.05;at 6 months post-operation, LVESV reduced (25.02±17.95) ml and at 12 months post-operation, it was further reduced (24.79±22.49) ml, both P<0.05. Compared with pre-operative condition, at 6 months post-operation, LVEDV dropped (25.61±24.24) ml, LVEDD dropped (3.22±2.91) mm, LVESD dropped (4.43±2.86) mm and MR grade dropped 0.49±0.76, all P<0.05. Compared with 6 months post-operation, at 12 months post-operation, LVEDV declined (28.18±22.36) ml, LVEDD declined (4.17±3.14) mm, both P<0.05, LVESD declined (4.92±4.40) mm, P<0.01 and MR grade declined (0.22±0.55), P<0.05.
Conclusion:CRT may reverse ventricular remodeling and improve cardiac function in patients with III°AVB combining systolic dysfunction.
