Study on Compatible Stability of Coenzyme A for Injection, Adenosine Disodium Triphosphate and Inosine Injection
- VernacularTitle:注射用辅酶A、三磷酸腺苷二钠及肌苷注射液配伍稳定性考察
- Author:
Zhen TANG
;
Lan XU
;
Xiaoxuan TAO
;
Chuanhua FENG
;
Lang ZHANG
;
Gang LI
- Keywords:
Coenzyme A;
Adenosine disodium triphosphate;
Inosine;
Compatibility;
Stability;
HPLC
- From:
China Pharmacist
2017;20(1):184-186
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the compatibility and stability of coenzyme A for injection, adenosine disodium triphosphate and inosine injection. Methods:By simulating the clinical medication, the three drugs and 5% glucose injection were mixed together. The contents and relative substances of coenzyme A, adenosine disodium triphosphate and inosine were measured by HPLC. The changes in appearance, pH and insoluble particles were observed or tested at ambient temperature. Results:The mixed solution showed no signifi-cant changes in appearance, pH, number of insoluble particles, contents and relative substances of coenzyme A, adenosine disodium triphosphate and inosine in 4 h, while the mixed solution became turbid and the pH, number of insoluble particles and contents of the three drugs showed significant changes after 24-h storage. Conclusion:The mixed solution of coenzyme A for injection, adenosine dis-odium triphosphate and inosine injection in 5% glucose injection should be used up in 4 h at ambient temperature.
