Solubilization of Meglumine on Repaglinide
- VernacularTitle:葡甲胺对瑞格列奈助溶作用的研究
- Author:
Kuikui LIU
;
Lin ZHANG
;
Xin LI
;
Ling WANG
- Keywords:
Meglumine;
Repaglinide;
Molecular complex;
Solubilization
- From:
China Pharmacist
2017;20(1):189-192
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the solubility of repaglinide in meglumine aqueous solution. Methods: In order to increase the solubility of repaglinide, meglumine was used to react with repaglinide and obtain a molecular complex. The structure and composition of meglumine-repaglinide complex was analyzed by DSC, HPLC and HPLC-MS. Results:Meglumine and repaglinide formed a molecu-lar complex, and their best molar ratio was 1 ∶1. With the concentration increase of meglumine, the solubility of repaglinide also in-creased. The stability of molecular complexes decreased with the temperature increase. Conclusion:Meglumine plays a good role in the solubilization of repaglinide.
