Effect of preoperative stellate ganglion block on gastrointestinal function in rats undergoing abdominal surgery
- VernacularTitle:术前星状神经节阻滞对大鼠腹部手术后胃肠功能的影响
- Author:
Haiyan LI
;
Dengyun XIA
;
Huiping WEI
;
Jiandong LI
- Keywords:
Stellate ganglion block;
Abdominal surgery;
Stress response;
Inflammatory re-action;
Gastrointestinal function
- From:
The Journal of Clinical Anesthesiology
2017;33(1):66-70
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of preoperative stellate ganglion block (SGB)on gastrointestinal function in rats undergoing gastrointestinal and non-gastrointestinal abdominal surgery.Methods Fifty-four male SD rats,weighing (200 ± 10 )g,were randomly divided into 5 groups:control group (n =6,group C),gastrointesinal abdominal surgery group (n =12,group G), SGB+gastrointesinal abdominal surgery group (n = 12,group SG),non-gastrointestinal abdominal surgery group (n = 12,group NG),SGB+ non-gastrointestinal abdominal surgery group (n = 12, group SNG).Group C was given no treatment.Venous blood samples were taken for determination of the levels of serum NE,TNF-αand IL-6 at the time before stellate ganglion block (T1 ),the end of operation (T2 ),12 h (T3 )and 24 h after operation (T4 ).Six rats were randomly chosen from each group to test bowel propulsion rate at T3 and T4 ,then sacrificed to measure motilin (MTL)and vaso-active intestinal peptide (VIP)in antrum and proximal colon.Results Compared with T1 and group C,the serum concentrations of NE,TNF-αand IL-6 significantly increased at T2-T4 in groups G,SG, NG and SNG (P <0.05).The NE,TNF-α and IL-6 levels in group G were significantly higher than those in group SG (P <0.05),and the serum NE,TNF-αand IL-6 levels in group NG were signifi-cantly higher than those in group SNG (P <0.05).Compared with T3 and group C,the bowel pro-pulsion rate and MTL levels significantly increased at T4 in groups G,SG,NG and SNG (P <0.05). The bowel propulsion rate and MTL levels in group SG and group SNG were significantly higher than those in group G and group NG,respectively (P <0.05 ).The VIP levels significantly decreased in groups G,SG,NG and SNG than that in group C (P <0.05).The VIP levels in group SG were sig-nificantly lower than those in group G (P < 0.05 ), and the VIP levels in group SNG were significantly lower than those in group NG (P < 0.05 ).Conclusion Preoperative stellate ganglion block can premote the recovery of gastrointestinal function in rats after abdominal surgery,attenuated stress response and inflammatory reaction,and regulation of gastrointestinal hormone level may be involved in the mechanism.
