Pharmacological effects of drugs mediated by calcitonin gene-related peptide:a review

VernacularTitle:降钙素基因相关肽介导的药物药理学效应
Author: Youcong YIN ; Yuanjian LI
Keywords: calcitonin-gene related peptide; nitroglycerin; rutaecarpine; capsaicin; sartans
From: Chinese Journal of Pharmacology and Toxicology 2017;31(1):112-118
CountryChina
Language:Chinese
Abstract: Calcitonin gene-related peptide (CGRP), a predominant neurotransmitter in sensory nerves, is widely distributed in central and peripheral tissues. In the cardiovascular system, besides relaxing vascular smooth muscle, CGRP protects against ischemic myocardium while inhibiting cardiac remodeling. The pharmacological effects of nitroglycerin and rutaecarpine have proved to be associated with the increase in the synthesis and release of CGRP. In gastrointestinal tissues, CGRP participates in the regulation of gastrointestinal function and has protective effects on the gastric mucosa. Rutaecar?pine, capsaicin and its derivatives can reduce gastric mucosa damage induced by a variety of factors by increasing synthesis and release of CGRP.