Preparation and Characterization of Scutellarin Nanosuspension
- VernacularTitle:灯盏乙素纳米混悬液的制备及其表征
- Author:
Rentong LIU
;
Xuediao PAN
;
Xiaohui LUO
;
Weisi LIN
;
Wenting LIU
;
Zhicheng YANG
- Keywords:
Scutellarin;
Nanosuspension;
High pressure homogenization;
Orthogonal experiment
- From:
China Pharmacist
2017;20(1):42-45
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To prepare scutellarin nanosuspension ( SCU-NS) and study the main influencing factors in the prepara-tion. Methods:The technology parameters were determined, and then the influencing factors of SCU-NS were studied. The optimal formula was confirmed by orthogonal design with zeta potential as the evaluation index. Results: The optimal formula process was as follows:drug amount was 0. 5 g, Pluronic? F68 amount was 0. 1 g, phospholipid amount was 0. 2 g, SDS amount was 0. 05 g and HPMC E5 amount was 0. 05 g. The average particle size and the zeta potential of SCU-NS was (122 ± 4) nm and ( -25. 5 ± 0. 6) mV, respectively. The result of transmission electron microscope showed that SCU-NS was spherical and uniform, and the dissolution of SCU-NS in 30 min was more than 90%. Conclusion:Nanosuspension can significantly enhance the dissolution of SCU.
