Research Progress in New Dosage Forms of Nevirapine
- VernacularTitle:奈韦拉平新剂型的研究进展
- Author:
Xiaona LIU
;
Lili CHE
;
Yanming WANG
;
Hongmei LIU
;
Jingling TANG
- Keywords:
Evirapine;
Bioavailability;
Solid dispersion;
Self-emulsifying;
Microparticles
- From:
China Pharmacist
2017;20(1):148-150
- CountryChina
- Language:Chinese
-
Abstract:
Nevirapine ( NVP) is the first-generation non-nucleoside reverse transcriptase inhibitor, which is a front-line drug for the treatment of AIDS and the prevention of mother-to-child transmission of HIV-1. NVP is with poor solubility and low bioavailability. With the development of new dosage forms, such as solid dispersion, self-emulsifying, microparticles, micelles, sustained-release tab-lets and floating microspheres, the bioavailability of NVP can be increased and the adverse reactions can be decreased. Research pro-gress in the new dosage forms of NVP at home and abroad was reviewed through searching literatures in order to provide basis for the development of new dosage forms of NVP.
