The latest developments in targeted therapy for triple-negative breast cancer

VernacularTitle:三阴性乳腺癌靶向治疗最新进展
Author: Zimei LIU ; Zan SHEN
Keywords: Triple-negative breast cancer; Target; Therapy
From: China Oncology 2017;27(1):36-40
CountryChina
Language:Chinese
Abstract: Triple-negative breast cancer (TNBC) is a special type of breast cancer, accounting for 15%-20% of all diagnosed breast cancer cases. Its estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor-2 (HER-2) expression is negative, with unique biological characteristics, clinicopathological features and tumor heterogeneity. Its clinical features include high incidence of relapse, early metastasis and poor prognosis. Currently, it lacks effective treatment. This review described the clinicopathological features of TNBC, its molecular subtypes, several important pathways and targets, as well as presented the progress in clinical studies of targeted drugs in the hope of generating new ideas for the treatment of TNBC in the future.