Study on the Effects of Disassembled Formulation of Xiaosuanzao Decoction on Spontaneous Motion and Sleep Time in Mice
10.6039/j.issn.1001-0408.2017.04.15
- VernacularTitle:小酸枣汤对小鼠自主活动及睡眠时间影响的拆方研究
- Author:
Lifeng ZHANG
;
Canfang LIU
- Keywords:
Xiaosuanzao decoction;
Disassembled formulation;
Orthogonal test;
Spontaneous motion;
Sleep time;
Mice
- From:
China Pharmacy
2017;28(4):487-489
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the effects of Xiaosuanzao decoction on spontaneous motion and sleep time in mice, and to study its disassembled formulation. METHODS:Seven ingredients of Xiaosuanzao decoction were selected as the influential factors, including Ziziphus jujuba, Poria cocos, Ligusticum chuanxiong, Anemarrhena asphodeloides, Glycyrrhiza uralensis, Zingiber officinale and Cortex cinnamoni. Two levels of with or without were designed for each factor,and the experiment was ar-ranged according to L8(27) orthogonal test table. The effects of Xiaosuanzao decoction and each ingredient on spontaneous motion within 2 min and sleep time induced by superthreshold dosage of pentobarbital sodium were compared by visual analysis method and analysis of variance. RESULTS:Z. jujube and A. asphodeloides were the main active ingredients of Xiaosuanzao decoction on spontaneous motion;Z. jujube was the main active ingredient of Xiaosuanzao decoction on sleep time induced by superthreshold dosage of pentobarbital sodium. CONCLUSIONS:Xiaosuanzao decoction can inhibit spontaneous motion and prolong sleep time in-duced by superthreshold dosage of pentobarbital sodium,and Z. jujube is the main ingredient of Xiaosuanzao decoction.
