Thirty years of research on toxicant metabolism and toxicokinetics in China
10.3867/j.issn.1000-3002.2016.12.012
- VernacularTitle:我国毒物代谢和毒代动力学研究三十年回顾
- Author:
Li HUA
- Keywords:
toxicokinetics;
metabolism;
chemical warfare agent;
toxic herbal drug;
pesticide;
environmental pollutant
- From:
Chinese Journal of Pharmacology and Toxicology
2016;30(12):1333-1342
- CountryChina
- Language:Chinese
-
Abstract:
Toxicant metabolism and toxicokinetics are an integrated part of toxicology. They study the absorption,targeted distribution,metabolic detoxicification or bioactivation,excretion and elimination of toxic substances after the body′s exposure via different routes,and also evaluate the effects of various factors on the disposition of poisons. The results of the studies provide essential data on the relation?ships between exposure kinetics and toxicological effect and their mechanisms. They also help to find possible targets of intoxication or detoxicification pathways,which can lead to efficient countermea?sures. In this review,the author summarized the thirty years of progress and features of the research on toxicant metabolism and toxicokinetics in China.
